Antimicrobial stewardship programs (ASPs) — designed to optimize antibiotic use and reduce the emergence of resistance — are experiencing unprecedented deployment across Africa thanks to support from the Fleming Fund, a British initiative with GBP 265 million in funding. By June 2026, 30 African countries have joined the program, up from just 8 in 2023. The ASPs implemented in participating hospitals are based on a multidisciplinary approach involving infectious disease specialists, pharmacists, microbiologists, and hospital managers. Interventions include developing treatment guidelines adapted to local contexts, establishing prior authorization systems for broad-spectrum antibiotics, continuous training for prescribing staff, and regular analysis of antibiotic consumption data. Preliminary results, presented at the Global AMR Conference in Geneva, are encouraging. In the 150 pilot hospitals, inappropriate antibiotic consumption decreased by an average of 15%, while median antibiotic treatment duration was reduced from 10 to 7 days with no negative impact on clinical outcomes. Savings on antibiotic purchases have been reinvested in microbiological diagnostics. Dr. Hanan Balkhy, WHO Assistant Director-General for Antimicrobial Resistance, praised this progress while noting that "scaling up remains the greatest challenge. We must transform these hospital-level successes into sustainable national policies." The Fleming Fund has announced an extension of its funding through 2030.